吴文柽 性别：男

学习经历：

（1）2013-09至2017-06, 中国矿业大学（北京）, 材料科学与工程, 学士

（2）2017-09至2022-06, 中国科学院大学, 材料物理与化学, 博士

工作经历：

（1）2022-07至2024-07, 中国科学院上海硅酸盐研究所博士后，助理研究员

（2）2024-08至今, 四川省医学科学院·四川省人民医院, 研究员

担任Nano TransMedicine，Biomaterials Translational，Exploration及Research期刊青年编委职务。

长期从事纳米药物开发，肿瘤催化治疗、免疫治疗、肿瘤免疫微环境调控及机制探索等研究工作。针对现有肿瘤治疗方式存在的局限性，设计各种新型纳米材料，开发肿瘤治疗新模式，为癌症高效、低毒治疗提供新思路。近5 年，以第一作者/共一/共同通讯作者身份在Nature Communications, Advanced Materials, Journal of the American Chemical Society（3 篇）, Journal of Controlled Release（2 篇）, Nano Today, Advanced Science（3 篇）, Research, Nano-Micro Letters, Biomaterials 等高影响力期刊上发表SCI 期刊论文20篇，影响因子大于10的19篇。申请中国发明专利8项，授权3项。申请人曾获得2024年度电子科技大学百人计划人才及2022年国家博士后创新人才之计划等项目。以参与人身份参与国家级项目3 项，其中包括国家重点研发计划“高端功能与智能材料”重点专项项目。近5 年代表性研究成果如下：

1. Wu, W. C., Yu, L. D. Jiang, Q. Z., Huo, M. F., Lin, H. Wang, L. Y., Chen, Y., Shi, J. L. Enhanced Tumor-Specific Disulfiram Chemotherapy by In Situ Cu2+ Chelation-Initiated Nontoxicity-to-Toxicity Transition. J. Am. Chem. Soc. 2019, 141, 11531-11539. (第一作者，IF = 14.4)

2. Wu, W. C., Yu, L. D. Pu, Y. Y., Yao, H. L., Chen, Y., Shi, J. L. Copper-Enriched Prussian Blue Nanomedicine for In Situ Disulfiram Toxification and Photothermal Antitumor Amplification. Adv. Mater. 2020, 32, 2000542. (第一作者，IF = 27.4)

3. Wu, W. C., Pu, Y. Y., Yao, Shi, J. L. Dual Size/Charge-Switchable Nanocatalytic Medicine for Deep Tumor Therapy. Adv. Sci. 2021, 8, 2002816. (第一作者，IF = 14.3)

4. Wu, W. C., Pu, Y. Y., Lin, H., Yao, H. L., Chen, Y., Shi, J. L. Starvation-Sensitized and Oxygenation-Promoted Tumor Sonodynamic Therapy by A Cascade Enzymatic Approach. Research, 2021, 9769867. (第一作者，IF = 8.5)

5. Wu, W. C., Pu, Y. Y., Lin, H., Yao, H. L., Shi, J. L. Microbiotic Nanomedicine for Tumor‐Specific Chemotherapy‐Synergized Innate/Adaptive Antitumor Immunity. Nano Today, 2022, 42, 101377. (第一作者，IF = 13.2)

6. Wu, W. C., Pu, Y. Y., Zhou, B. G., Shen, Y. C., Gao, S., Zhou, M., Shi, J. L. Photoactivatable Immunostimulatory Nanomedicine for Immunometabolic Cancer Therapy. J. Am. Chem. Soc. 2022, 144, 41, 19038-19050. (第一作者，IF = 15)

7. Wu, W. C., Pu, Y. Y., Shen, Y. C., Gao, S., Zhou, M., Yao, H. L., Shi, J. L. Bacterial Metabolism-Initiated Nanocatalytic Tumor Immunotherapy. Nano-Micro lette. 2022, 14, 220. (第一作者，IF = 31.6)

8. Wu, W. C., Pu, Y. Y., Shi, J. L. Transitional Metals-Based Nanocalalytic Medicine for Tumor Therapy. Adv. Healthc. Mater. 2021, 2001819 (第一作者，IF = 10)

9. Wu, W. C., Pu, Y. Y., Shi, J. L. Nanomedicine-enabled chemotherapy-based synergetic cancer treatments. J. Nanobiotechnology 2022, 20, 4. (第一作者，IF = 10.2)

10. Zhu, P. Pu, Y. Y., Wang, M., Wu, W. C.*, Qin, H. L., Shi, J. L.* MnOOH-Catalyzed Autoxidation of Glutathione for Reactive Oxygen Species Production and Nanocatalytic Tumor Innate Immunotherapy. J. Am. Chem. Soc. 2023, 145, 10, 5803-5815. (共同通讯作者，IF = 14.4)

11. Chen, M. Q., Shen, Y. C., Pu, Y. Y., Zhou B. G., Bing, J. L., Ge, M., Zhu, Y. X., Gao, S., Wu, W. C.*, Zhou, M., Shi, J. L.* Biomimetic inducer enabled dual ferroptosis of tumor and M2-type macrophages for enhanced tumor immunotherapy. Biomaterials 2023, 303, 122386. (共同通讯作者，IF = 12.8)

12. Pu, Y. Y., Zhou, B. G., Bing, J. H., Wang, L. Chen, M. Q., Shen, Y. C., Gao, S., Zhou, M., Wu, W. C.*, Shi, J. L.*, Ultrasound-triggered and glycosylation inhibition-enhanced tumor piezocatalytic immunotherapy. Nat. Commun. 2024. 15, 9023. (共同通讯作者，IF = 14.7)

13. Bing, J. H., Zhou, B. G., Chen, M. Q., Shen, Y. C., Zhou, M., Lin, H., Wu, W. C.*, Shi, J. L.*. Nanomedicine-enabled concurrent regulations of ROS generation and copper metabolism for sonodynamic-amplified tumor therapy. Biomaterials 2025, 318, 123137. (共同通讯作者，IF = 12.8)

14. Pu, Y. Y., Duan, Y. Y., Li, W. H., Lin, H., Li, Q. Y., Yin, B. X., Zhang, Kun*, Zhou, B. G*. Wu, W. C.*. A cerium single-atom catalyst enables targeted catalytic therapy for acute kidney injury via neutrophil hitchhiking. J. Control. Release 2025, 380, 404-416. (末位通讯作者，IF = 10.5)

15. Li, M. D., Zhou, Y. J., Chen, X. Y., Chen, W. W., Yang, Y. F., Qian, C., Yang, L., Zhang, Y. H., Zhang, Z.*, Wu, W. C.*, Yin, Y. F*. Engineered Nanocatalyst‐Enabled Cheolesterol Depletion for Enhanced Tumor Piezocatalytic Therapy. Adv. Sci. 2025, 318, 123137. (共同通讯作者，IF = 14.3)

16. Zhou, B. G., Y. Y., Duan, Y. Y., Li, W. H., Chen, T., Wang, J. C., Cao, M. T., Lin, G. H., Yang, K.*, Lai, Z. Q. *, Wu, W. C.* A Tailored Hydrogel with Local Glycemia Management, Antioxidant Activity, and Photothermal Antibacterial Properties for Diabetic Wound Healing. Adv. Sci. 2025, 2414161. (末位通讯作者，IF = 14.3)

2020年获博士研究生国家奖学金；2020年获严东生奖学金；2022年获中国科学院院长优秀奖；2022年获上海市高等学校优秀毕业生；2023年获中科院优秀博士论文。